1 A native interactor scaffolds and stabilizes toxic Ataxin - 1 oligomers in SCA
نویسندگان
چکیده
A native interactor scaffolds and stabilizes toxic Ataxin-1 oligomers in SCA1 1 C.A. Lasagna-Reeves, M.W.C. Rousseaux, M.J. Guerrero-Munoz, J. Park, 2 P. Jafar-Nejad,R. Richman, N. Lu, U.Sengupta, A. Litvinchuk, 3 H.T. Orr, R. Kayed and H.Y. Zoghbi * 4 5 1 Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030 6 2 Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX 77030 7 3 Department of Neurology, University of Texas Medical Branch, Galveston, TX 77555 8 4 Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030 9 5 Institute for Translational Neuroscience, University of Minnesota, Minnesota 55455 10 11 12 13 *Corresponding author: 14 15 Huda Zoghbi, MD. 16 Jan and Dan Duncan Neurological Research Institute 17 1250 Moursund St., Suite N.1350 18 Houston, TX 77030 19 Phone: 713-798-6558 20 Fax: 713-798-8728 21 [email protected] 22 23
منابع مشابه
A native interactor scaffolds and stabilizes toxic ATAXIN-1 oligomers in SCA1
Recent studies indicate that soluble oligomers drive pathogenesis in several neurodegenerative proteinopathies, including Alzheimer and Parkinson disease. Curiously, the same conformational antibody recognizes different disease-related oligomers, despite the variations in clinical presentation and brain regions affected, suggesting that the oligomer structure might be responsible for toxicity. ...
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